Since the observation that certain substances acquire antirachitic properties following exposure to ultraviolet rays,1 great interest has centered on the artificial production of vitamin D and on its relationship to the diseases concerned with calcium metabolism. Soon after the initial discoveries, it was established2 by a series of brilliant investigations that the specific substance activated by irradiation was ergosterol. The efficacy of viosterol (irradiated ergosterol) in the treatment of rickets and osteomalacia was quickly established. In addition, workers3 studied the effects of this material on normal laboratory animals. They demonstrated that an elevation of the blood calcium occurred and that calcium was deposited in the arterial walls, especially the aorta, and in the muscle of the heart, the wall of the stomach, the lungs and the kidneys. In still other experiments4 it was shown that even more widespread calcification occurred, and that the animals frequently had
SPIES TD. PRODUCTION OF NONFATAL VASCULAR SCLEROSIS IN RABBITS BY MEANS OF VIOSTEROL (IRRADIATED ERGOSTEROL). Arch Intern Med (Chic). 1932;50(3):443–449. doi:10.1001/archinte.1932.00150160094011
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