In recent experimental and clinical studies of diuretics, much attention has been devoted to correlation of quantitative changes in blood and urinary metabolites, especially the chlorides, with the object of determining the seat of diuretic action. The significance of the correlations has been about as follows: simultaneous increases in blood and urinary chlorides and in the output of urine reflect a direct and general action of the diuretic on the tissues, whereas a reciprocal change in the blood and urinary chlorides, i. e., a decrease in blood chlorides with a simultaneous increase in urinary chlorides and an increase in the output of the urine, reflect indirect effects through circulatory or renal changes, or both. These effects have been described for a number of diuretics, chemically and pharmacologically different. For instance, Hartzieganu, Gavrila and Borbil1 demonstrated concurrent increases in blood and urinary chlorides during diuresis after mersalyl and merbaphen, in
STOCKTON AB. DIURETIC EFFECTS AND CHANGES IN BLOOD AND URINARY METABOLITES AFTER DIGITALIS IN NORMAL AND IN EDEMATOUS PERSONS. Arch Intern Med (Chic). 1932;50(3):480–487. doi:10.1001/archinte.1932.00150160131014
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