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October 1932


Author Affiliations


From the Department of Obstetrics and Gynecology, Washington University, School of Medicine, the St. Louis Maternity Hospital, and the Department of Obstetrics and Gynecology, University of Chicago.

Arch Intern Med (Chic). 1932;50(4):574-578. doi:10.1001/archinte.1932.00150170066006

Methemoglobinemia occurring spontaneously is rare, and a case of twenty-seven years' duration is, so far as I know, unheard of. The first cases were described in 1902, by Stokvis1 and Talma,2 who considered the cyanosis to be due to methemoglobin, but van den Bergh,3 in 1905, in a study of two cases, was able to distinguish two types of this condition, which had been known and is still known as "enterogenous cyanosis." He showed that the cyanosis was due in one of his cases to sulphemoglobin and in the other to methemoglobin circulating in the blood. Up to that time there had been no differentiation between the two types, and some doubt, therefore, arises as to the true nature of the cases described by Stokvis and Talma. Excluding their four cases because of this doubt, I have been able to collect the following reports of six cases

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