Sickle cell anemia, since its description by Herrick1 in 1910, has become established as a well defined disease entity. The clinical picture is so distinctive that a tentative diagnosis of the condition can be made from the history and physical signs before the examination of the blood is completed. While the disease is relatively frequent in some sections of the country, perhaps on account of its familial tendency and the drawing power of the more celebrated clinics, nevertheless, it is rare in this vicinity, the only other case in Houston brought to my attention, besides the one to be reported, having been published by Milliken2 in 1928. Sydenstricker3 reported a ratio of 1 case to every 400 Negro patients seen in his clinic, but the incidence in this locality is almost certainly not so high, as I and my associates have been constantly on the lookout for
BRANDAU GM. SICKLE CELL ANEMIA: REPORT OF A CASE. Arch Intern Med (Chic). 1932;50(4):635–644. doi:10.1001/archinte.1932.00150170127012
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