Elevation of the serum protein content, except in dehydration, is observed rarely in clinical practice. Even with marked loss of fluid from the body the increase of protein in the blood usually is not great. True hyperproteinemia is exceedingly rare. Loeper, Forestier and Tonnet1 found the serum protein to be 11 mg. per hundred cubic centimeters in one case of malignant tumor of the kidney. Wu2 reported that one patient with kala-azar had a serum protein of 10.52 mg. and a serum globulin of 9.06 mg. The highest serum protein content observed by Rowe3 was 10.4 mg. in a patient suffering from glandular enlargement. However, no known clinical syndrome shows constantly an increase in the protein of the blood.
Few studies on proteins of the blood in patients with multiple myelomas have been reported. Ellinger4 demonstrated qualitatively the presence of Bence-Jones protein in blood and in
SHIRER JW, DUNCAN W, HADEN RL. HYPERPROTEINEMIA DUE TO BENCE-JONES PROTEIN IN MYELOMATOSIS. Arch Intern Med (Chic). 1932;50(6):829–835. doi:10.1001/archinte.1932.00150190031003
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