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February 1933

The Cardiac Output of Man in Health and Disease.

Arch Intern Med (Chic). 1933;51(2):326. doi:10.1001/archinte.1933.00150210156014

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As is suggested by the title, this monograph discusses cardiac output in a most comprehensive fashion. It includes a bibliography of 483 references.

A history of the early attempts to estimate cardiac output is followed by an account of the more important investigations that have led to the establishment of the direct and indirect methods for the determination now in use. Several indirect methods are compared in regard to their relative accuracy, and the advantages and disadvantages of each one are analyzed. The general principles and technical details of the acetylene method advocated by the author are described.

The effect of various physiologic factors which may influence cardiac output is emphasized. The section of the book relating to this matter is perhaps the most notable part of the volume, since the author establishes by his own method, in a series of carefully executed determinations, a set of normal values essential

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