HYPERPLASTIC SCLEROSIS OF THE PULMONARY ARTERY AND ARTERIOLES: REPORT OF A CASE WITH DISCUSSION OF THE PATHOGENESIS

Sclerosis of the pulmonary artery and arterioles associated with Ayerza's syndrome occurs secondary to a variety of diseases, congenital and acquired, of the heart, lungs, pericardium, pleura and blood vessels (Miller¹). Primary sclerosis developing independently of these conditions is much less frequent. The majority of the latter cases are due to syphilis (Rogers,² Warthin,³ Arrillaga,⁴ Elizalda,⁵ Hare and Ross,⁶ Thomas,⁷ Bruce and co-workers,⁸ Cheney,⁹ Weber and Bode¹⁰ and Konstam and Turnbull¹¹); a few to rheumatic fever (Paul¹²). In a smaller group the lesion is hyperplastic and noninflammatory and the etiology obscure (Rosenthal,¹³ Bacon and Apfelbach¹⁴).

REPORT OF CASE  G. P., a stevedore, white, aged 48, was first seen in October, 1924, complaining of a cough productive of a small amount of mucus, a feeling of constriction across the upper part of the chest and dyspnea, which had developed over a period of five years. The family