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"When a man's knowledge is not in order, the more of it he has the greater will be his confusion." This is the embarrassing situation, certainly, in which most physicians have found themselves as regards the relation of the endocrine glands to medicine. As a matter of fact, one wonders whether endocrinology as a workable "specialty" is destined to endure either in physiology or in clinical medicine. Diabetes has long since and by common consent detached itself, because, as every one knows, special training in physiologic chemistry and in nutrition is necessary for the adequate handling of diabetic problems. The endocrinology of the female is being preempted more and more by men with a sound gynecological background; the recent dramatic progress in the knowledge of disorders of the parathyroid gland comes from physiologically minded and chemically trained internists, and physiologists and general internists seem to be on the front line