Diffuse ulceration of the esophagus, of a degree sufficient to produce esophageal symptoms, is very unusual in the absence of obstruction. A lesion of this type was found in the first case that we report. We had not previously observed such diffuse ulceration except at necropsy, when in all probability postmortem changes were at least partly responsible. Similarly, we had not observed diffuse ulcerative tracheitis, as in the second case. That both of these uncommon lesions occurred in persons with diabetes suggests an etiologic factor in the metabolic abnormality. That patients with uncontrolled diabetes have a predilection for infectious diseases is attested by general experience, but, so far as we have learned, the complications considered here have not been reported in the literature on diabetes.
REPORT OF CASES
Case 1.—Lesion of the Esophagus.
—A farm laborer, 24 years of age, manifested abruptly the cardinal symptoms of diabetes. Two weeks later,
VINSON PP, WILDER RM. DIFFUSE ULCERATION OF THE ESOPHAGUS AND TRACHEA ASSOCIATED WITH DIABETES MELLITUSABSENCE OF ARTERIOSCLEROSIS. Arch Intern Med (Chic). 1933;52(4):541–544. doi:10.1001/archinte.1933.00160040047002