A study of the effect of lack of the vitamin B complex on gastric secretion is of interest for several reasons. The first is based on analogy and is concerned with that vicious circle of pernicious anemia, gastric achylia and subacute combined sclerosis. This group of symptoms has been termed "combined system disease." The relationships of the elements of this syndrome are fascinating in their implications. It is well recognized that practically all cases of pernicious anemia are characterized by gastric achylia. In support of this view, observations of Minot and Murphy1 and others indicating that pernicious anemia may well be classified as a deficiency disease, and the findings of Castle2 that impaired gastric function plays an important rôle, may be cited. According to some investigators in this field (Hurst and Bell,3 Collier4 and Vanderhoof5), there is an almost invariable association of achylia gastrica with combined sclerosis of the spinal
COWGILL GR, GILMAN A. PHYSIOLOGY OF VITAMINS: XXIII. THE EFFECT OF LACK OF THE VITAMIN B COMPLEX ON THE SECRETION OF GASTRIC JUICE IN DOGS WITH GASTRIC POUCHES. Arch Intern Med (Chic). 1934;53(1):58–70. doi:10.1001/archinte.1934.00160070063006
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