The cyclic nature of biologic phenomena is by no means confined to normal physiologic processes. The occurrence of cycles in pathologic states is well illustrated by the tendency to remissions and exacerbations which is a characteristic of chronic ulcerative colitis. The joy of the patient and the enthusiasm of the physician at the successful treatment and termination of an attack must always be tempered by the sober realization that the condition may recur. Knowledge of the pathologic changes that take place in this disease leads to a clear understanding of the inherent tendency to recurrence. This analytic study was undertaken in an effort to throw light on the factors which determine the incidence of, or which actually precipitate, the exacerbations, with the hope that the knowledge thus gained will prove valuable in prophylaxis during the quiescent stage or during the period in which the disease is under control. Our attention
BANKS BM, BARGEN JA. RELAPSES IN CHRONIC ULCERATIVE COLITIS: CAUSES AND PREVENTION. Arch Intern Med (Chic). 1934;53(1):131–139. doi:10.1001/archinte.1934.00160070136011
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