One of the most perplexing, and yet one of the most interesting problems encountered in medical practice in general, and in clinical neurology in particular, is constituted by that group of patients who are suffering from some form of muscular atrophy or dystrophy.
Perhaps the first complete descriptions of the various forms of muscular dystrophy and atrophy were presented about the middle of the nineteenth century during the time of Charcot1 and his colleagues. Since that time numerous investigators have studied the problem in its various phases, and much information has been added toward a thorough comprehension of the characteristic clinical syndromes, with their associated pathologic lesions. Various theories as to the etiology of the condition have been presented and many therapeutic measures have been proposed, none of which have withstood the test of time.
The results of many studies have shown that in cases of muscular dystrophy the
TRIPOLI CJ, BEARD HH. MUSCULAR DYSTROPHY AND ATROPHY: CLINICAL AND BIOCHEMICAL RESULTS FOLLOWING THE ORAL ADMINISTRATION OF AMINO-ACIDS. Arch Intern Med (Chic). 1934;53(3):435–452. doi:https://doi.org/10.1001/archinte.1934.00160090112010
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