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March 1934

Handbook of Chemotherapy. Part I: Metal-Free Organic Compounds.

Arch Intern Med (Chic). 1934;53(3):480. doi:10.1001/archinte.1934.00160090157016

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This handbook represents the collaboration of a chemist and a physician. It contains therefore, detailed accounts of the chemistry of therapeutic preparations with which it deals and the opinions of the physician on the clinical results of their use. This volume is devoted to metal-free organic compounds. These are divided into eleven groups: acyclic chlorine compounds; unsaturated fatty acids; simple derivatives of benzene and naphthalene, oxy and oxo compounds; aminoacids; derivatives of quinoline (with the exception of quinine) and similar substances; quinine and its derivatives; emetine and its derivatives; the other plant substances; derivatives of acridine; the other dyestuffs, and colorless derivatives of urea.

In the discussion of such recognized chemotherapeutic agents as quinine and chaulmoogra oil, a splendid historical account of their early empirical use is given, with a satisfactory discussion of their method of action, presented in an unprejudiced manner. The same method of approach is employed in

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