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Article
June 1934

CHANGES OF THE DIGESTIVE TRACT IN UREMIA: A PATHOLOGIC ANATOMIC STUDY

Author Affiliations

CHICAGO

From the Department of Pathology, Cook County Hospital, and the Uihlein Memorial Laboratory, Grant Hospital.

Arch Intern Med (Chic). 1934;53(6):851-864. doi:10.1001/archinte.1934.00160120045005
Abstract

Although the gastro-intestinal manifestations of uremia have attracted much attention and numerous contributions deal with their symptomatology, the literature contains but few systematic studies of the underlying pathologic-anatomic changes. The severe necrotizing and ulcerative lesions of the intestine especially are of great interest and have caused much controversy as to their frequency and pathogenesis. While some authors consider a dysentery-like inflammation of the colon and, partially, also of the ileum as one of the most characteristic postmortem observations in uremia, Siegmund,1 in a recent review on the subject, came to the conclusion that the severe changes are rare. This is in agreement with statements found in the older literature (Pineau,2 Fédou,3 Fischer4 and others). Working in Kundrat's institute, Fischer found ulceration of the colon in only 4 of 17 cases of uremia. The majority of the patients showed only a swelling of the mucosa with superficial,

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