Interest in the group of diseases characterized by diffuse demineralization of the bones has been stimulated within the last decade by the increase in knowledge of calcium metabolism brought about by the studies of Aub and his co-workers, by the demonstration of the rôle played by vitamin D and, notably, by the discovery of parathormone. The preparation by Collip1 of a potent extract of the parathyroid glands made possible the establishment of clinical criteria for the diagnosis of hyperparathyroidism. That Recklinghausen's disease (osteitis fibrosa cystica) is due to parathyroid tumor and is relieved by parathyroidectomy was first demonstrated by Mandl;2 subsequent investigations have established that the clinical symptoms of this disease are dependent on hyperparathyroidism.
Genuine osteomalacia is a rare disease, particularly in males. Recent studies indicate that deficiency in vitamin D is primarily responsible. The metabolic changes characteristic of hyperparathyroidism have not been demonstrated. Enlargement of the
GUNN FD, NADLER WH. OSTEOMALACIA: NECROPSY OBSERVATIONS IN A MAN. Arch Intern Med (Chic). 1934;54(1):145–157. doi:https://doi.org/10.1001/archinte.1934.00160130148010
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