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Article
August 1934

PERNICIOUS ANEMIA: PARENTERAL TREATMENT WITH EXTRACTS PREPARED FROM DIGESTED EQUINE LIVER AND FROM SELF-DIGESTED STOMACH

Author Affiliations

ROCKFORD, ILL.; CHICAGO

From the Laboratories of the Chappel Foundation for Organotherapeutic Research, Rockford, Ill., and Cook County Hospital, Chicago.

Arch Intern Med (Chic). 1934;54(2):281-288. doi:10.1001/archinte.1934.00160140124007
Abstract

The presence of an antianemic factor in hog stomach and its therapeutic effectiveness in the treatment of pernicious anemia were discovered by Sharp1 and Sturgis and Isaacs.2 The active principle present in stomach tissue was found to be thermolabile, and could not be extracted by the method of Cohn, used in preparing liver extracts. They further found that no therapeutic response was obtained when either the muscularis or the mucosa of the stomach was fed separately. It was necessary to administer both in order to obtain the active principle. This suggested that the interaction of an enzyme on protein, present in the whole stomach tissue, occurred after the organ was removed. However, the observations of Castle,3 that by the action of normal gastric juice on muscle meat the active factor was formed, and of Morris,4 that normal gastric juice contains this principle, indicated that the substance

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