Since hyperthyroidism was first recognized, numerous investigators have attempted to discover a substance capable of inhibiting the action of the thyroid hormone. In the earlier attempts milk, meat and serum of thyroidectomized animals was used. Later serum of myxedematous persons was tried. None of these substances was capable of withstanding the critical tests of the laboratory and the clinic.
Other substances, nonspecific in character, have been reported as having a protective action against thyroxin, U.S.P., poisoning. Abelin1 found that certain nutritional mixtures prevented the rise in the metabolic rate after injections of thyroxin. Hesse2 reported the favourable action of metals, such as copper, arsenic and iron, and the waters of wells that contain these metals in prolonging the life of dogs which received daily injections of thyroxin. Certain vitamins are said to be able to a certain degree to prevent hyperthyroid manifestations.
Within the last year two new
HOFFMANN MH. EFFECT OF THYROXIN AND ANTITHYROID SUBSTANCES ON THE SERUM LIPASE. Arch Intern Med (Chic). 1934;54(3):427–435. doi:10.1001/archinte.1934.00160150114008
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