During the past fifteen years intensive investigations of chronic nephritis have brought about remarkable changes in the conception of many of its features. The disturbances of mineral, protein and water metabolism and their relationship to symptoms as well as to histologic changes have been worked out in some detail. The studies of acute nephritis, especially in the adult, are comparatively few, and this disease is less well understood than the chronic form.
It is almost universally accepted that chronic glomerular nephritis develops as the result of an acute attack which remains unhealed. Yet no extended experience with the chronic form is necessary to show that in most cases a history of an acute attack is lacking. In many cases the acute attack is so mild that the disease passes unnoticed, and the first evidence of a damaged kidney appears months or years later with the development of the signs and
MURPHY FD, GRILL J, MOXON GF. ACUTE DIFFUSE GLOMERULAR NEPHRITIS: STUDY OF NINETY-FOUR CASES WITH SPECIAL CONSIDERATION OF THE STAGE OF TRANSITION INTO THE CHRONIC FORM. Arch Intern Med (Chic). 1934;54(4):483–508. doi:10.1001/archinte.1934.00160160002001
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