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Article
October 1934

EFFECT OF CARDIAC INFARCTION ON THE TOLERANCE OF DOGS TO DIGITALIS: AN EXPERIMENTAL STUDY

Author Affiliations

PHILADELPHIA

From the Robinette Foundation and the Laboratory of Research Surgery, University of Pennsylvania, and the Division of Cardiology, Philadelphia General Hospital.

Arch Intern Med (Chic). 1934;54(4):509-516. doi:10.1001/archinte.1934.00160160028002
Abstract

The literature concerning the tolerance to digitalis in clinical cases of coronary occlusion is meager. The few reports with which we are acquainted consist chiefly of clinical impressions. Moreover, the conclusions of various observers are not entirely in agreement. Herrick1 stressed the great value of digitalis in coronary occlusion and suggested that rapid effects be sought in some cases by intravenous or intramuscular injection. Riesman2 felt that digitalis should not be used in coronary occlusion, believing that because of its great damage to the myocardium it would do no good and might do harm. Bastedo3 stated that in cases of coronary sclerosis and myocarditis, regardless of rhythm, digitalis must be used with care and never in massive doses.

Conclusions based on experiments with animals likewise are somewhat at variance. Gold4 reported in 1925 that there was no significant variation in the tolerance of cats to ouabain

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