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Article
October 1934

RELATIONSHIP BETWEEN OXYGEN CONSUMPTION AND NITROGEN METABOLISM: IV. EXPERIMENTS ON ANIMALS

Author Affiliations

IOWA CITY

From the Department of Physiology, University of Chicago.

Arch Intern Med (Chic). 1934;54(4):517-539. doi:10.1001/archinte.1934.00160160036003
Abstract

Variations in the rate of oxygen consumption are met with in numerous conditions in which no disturbance in thyroid function has been recognized. Prominent among such conditions are the hematopoietic diseases. In a series of investigations I have attempted to evaluate some of the abnormal physiologic processes in the blood dyscrasias in terms of their effect on the oxidative processes of the organisms as a whole. Studies have been made on patients with pernicious anemia, leukemia and polycythemia vera, as well as on dogs with acute hemorrhagic anemia, hemolytic anemia, induced polycythemia and phlorhizin diabetes.

The previous communications concerning pernicious anemia, leukemia and polycythemia vera will be briefly summarized. The reader is referred to the original publications for details and bibliographies.

STUDIES ON MAN 

Pernicious Anemia.  —The object of the studies of pernicious anemia, which were carried out by my associates and me was to determine the effect of rapid

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