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October 1934


Author Affiliations


From the Laboratory of Biochemistry, Jefferson Hospital.

Arch Intern Med (Chic). 1934;54(4):540-551. doi:10.1001/archinte.1934.00160160059004

Increasing recognition of the valuable information which may be derived from studies of hepatic function has resulted in the accumulation of a large quantity of data in this connection in recent years. In my experience, however, too little emphasis has been placed on such studies in the field in which they are of greatest value, namely, in the preoperative study of patients with disease of the gallbladder and bile ducts. This point was stressed in a previous report1 of a study of 234 patients with calculous and noncalculous cholecystitis, 70 of whom presented hyperbilirubinemia or bromsulphalein retention or both. The present report is a continuation of that study, with a more detailed presentation of the findings in a much larger series of patients.

During the years from 1931 to 1933, various studies of hepatic function were performed in 512 cases of cholecystitis and cholelithiasis; 49 of these were acute