We have shown that single large doses of thyroxine in alkaline solution have about 63 per cent as much effect when administered by mouth as when given intravenously.1 However, the oral administration of the monosodium salt in tablet form produces only about 25 per cent as much effect as the intravenous administration of thyroxine in alkaline solution, when the comparison is made on the basis of the daily doses of the two substances required for maintenance of the basal metabolism of patients with myxedema at the normal level.2 As a continuation of our study of the calorigenic action of various forms of thyroxine we have now determined the effects of administering single large doses of pure thyroxine both by mouth and directly into the duodenum, and have compared them with the effects of oral administration of single large doses of monosodium thyroxine in tablet form and of thyroxine
THOMPSON WO, THOMPSON PK, TAYLOR SG, DICKIE LFN. ORAL AND DUODENAL ADMINISTRATION OF SINGLE LARGE DOSES OF PURE THYROXINE: COMPARISON OF CALORIGENIC EFFECTS WITH THOSE OF MONOSODIUM THYROXINE AND THYROXINE IN ALKALINE SOLUTION. Arch Intern Med (Chic). 1934;54(5):818–828. doi:https://doi.org/10.1001/archinte.1934.00160170161013
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