The introduction of liver for the treatment of pernicious anemia by Minot and Murphy has provided an efficacious method of increasing the number of red blood cells and the percentage of hemoglobin to figures approaching normal, thereby relieving the general asthenic symptoms and prolonging the lives of patients indefinitely. The effect of liver on the neurologic complications of pernicious anemia also has been studied with great interest, but with the use of less certain criteria on which conclusions may be based. The literature already contains reports of several studies carried out over long periods of time which seem to indicate both prophylactic and curative values of liver extracts on the neurologic complications. However, some clinicians attributed an indirect action to the liver and suggested that the usual gain in general strength enhances the patient's powers of compensation for his neurologic defects, while others denied any noteworthy change in the nervous
GRINKER RR, KANDEL E. PERNICIOUS ANEMIA: RESULTS OF TREATMENT OF THE NEUROLOGIC COMPLICATIONS. Arch Intern Med (Chic). 1934;54(6):851–871. doi:10.1001/archinte.1934.00160180025003
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