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Article
December 1934

CALORIGENIC ACTION OF SINGLE LARGE DOSES OF DESICCATED HOG THYROID: COMPARISON WITH THE ACTION OF THYROXINE GIVEN ORALLY AND INTRAVENOUSLY

Author Affiliations

CHICAGO

From the Department of Medicine, Rush Medical College and the Presbyterian and Cook County hospitals.

Arch Intern Med (Chic). 1934;54(6):888-900. doi:10.1001/archinte.1934.00160180062005
Abstract

Several reports have recently been made from this clinic concerning the effects of administering thyroxine in various forms orally and intravenously in an alkaline solution.1 These observations have shown that single doses of from 10 to 100 mg. of pure thyroxine administered by mouth or duodenum do not have a demonstrable effect on the basal metabolism of patients with myxedema, whereas the oral administration of single large doses of monosodium thyroxine and thyroxine in alkaline solution causes increases in the basal metabolism of 22 and 63 per cent, respectively, as great on the average as the increase produced by the intravenous injection of an alkaline solution. It seemed important to determine the effect of single large doses of desiccated thyroid of the same iodine content for comparison with these data. We have previously reported observations which suggest that the oral administration of desiccated thyroid and the intravenous injection of

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