My interest in the rôle played by mucin in the physiology of the gastro-intestinal tract and the management of gastroduodenal ulceration was stimulated by Lim's publication, "On the Relationship Between the Gastric Acid Response and the Basal Secretion of the Stomach."1 At the lower secretory rates the concentration of mucus is undoubtedly higher than during the more active phases of gastric secretion. Many clinicians have noted a decreased secretion of mucus in patients with ulcer.2 It is likewise noteworthy that the many patients with ulcer rarely return to a normal basal secretory state. My objective, therefore, was to feed mucin to patients with ulcer in an attempt to correct the mucin deficiency as well as to restore normal basal secretory rates. By 1929 I had prepared a gastric mucin adequate for experimental and clinical investigation. The first clinical report on the treatment of gastroduodenal ulceration with gastric mucin
FOGELSON SJ. GASTRIC MUCIN TREATMENT FOR PEPTIC ULCER: A REPORT BASED ON QUESTIONNAIRES. Arch Intern Med (Chic). 1935;55(1):7–16. doi:https://doi.org/10.1001/archinte.1935.00160190010002
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