Into the subject "disease of metabolism" there now come not only diabetes, gout, obesity and a few other conditions involving chemical abnormalities of the body fluids, as formerly, but disturbances of the glands of internal secretion which affect the metabolic processes and disorders of nutrition which result from the lack in the food of adequate quantities of vitamins and other food factors. The desirability of the broader concept of the subject has been made apparent by the recent identification and separation, in many cases in pure crystalline form, of several of the hormones and vitamins. This has brought a fuller realization that the chemical reactions that constitute the metabolic process are dependent on the presence in suitable quantities of these specific catalysts. An instance in point is furnished by the recent rapid advancement of the knowledge of the physiology of the anterior lobe of the pituitary body. The new knowledge
WILDER RM, WILBUR DL. DISEASES OF METABOLISM AND NUTRITION: REVIEW OF CERTAIN RECENT CONTRIBUTIONS. Arch Intern Med (Chic). 1935;55(2):304–343. doi:https://doi.org/10.1001/archinte.1935.00160200134009
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