These studies were initiated in the attempt to utilize the effects of iodides and salicylates on the excretion of nitrogen and sulphur1 in the study of Bright's disease. It has been shown previously that iodides and salicylates mobilize different types of nitrogen and that the effect of iodide is produced by the mediation of the thyroid gland.2 When an attempt was made to conduct similar studies on patients with renal disease, it was observed that patients with the nephrosis syndrome showed a relationship between the amount of nitrogen and the amount of sulphur excreted in the urine similar to that exhibited by persons as an effect of the administration of iodides, whereas patients with other types of renal disease showed a totally opposed relationship between these two urinary constituents. Further studies indicated that the reaction to iodides and salicylates in patients with Bright's disease3 was different from
GRABFIELD GP, ADAMS LG. NITROGEN AND SULPHUR METABOLISM IN BRIGHT'S DISEASE: VI. EFFECT OF DIETS LOW IN SULPHUR ON THE EXCRETION OF SULPHUR. Arch Intern Med (Chic). 1935;55(3):360–370. doi:https://doi.org/10.1001/archinte.1935.00160210013002
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