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March 1935


Author Affiliations


From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard University Medical School (Dr. Chew and Dr. Stetson), with the cooperation of the Fearing Research Laboratory of the Free Hospital for Women, Brookline, Mass. (Drs. Smith).

Arch Intern Med (Chic). 1935;55(3):431-444. doi:10.1001/archinte.1935.00160210084008

In another communication1 observations were reported on seven patients with hemophilia in whom no demonstrable improvement in the coagulation of the blood or in the clinical state resulted from the oral and parenteral administration of various ovarian and estrogenic substances.

The failure to enhance the coagulability of the blood in hemophilia by the administration of an estrogenic substance has been noted by Blaylock,2 who observed a slight increase in the coagulation time of the blood of his patient with hemophilia one week after starting daily subcutaneous injections of an "ovarian preparation obtained from the fetal fluid of cattle." Brown and Albright3 similarly observed no beneficial effect in one patient with hemophilia who was given injections of large amounts of estrogenic substance over a period of three days. More recently, Brem and Leopold4 have reported negative observations on the coagulation time and clinical state of a patient