In another communication1 observations were reported on seven patients with hemophilia in whom no demonstrable improvement in the coagulation of the blood or in the clinical state resulted from the oral and parenteral administration of various ovarian and estrogenic substances.
The failure to enhance the coagulability of the blood in hemophilia by the administration of an estrogenic substance has been noted by Blaylock,2 who observed a slight increase in the coagulation time of the blood of his patient with hemophilia one week after starting daily subcutaneous injections of an "ovarian preparation obtained from the fetal fluid of cattle." Brown and Albright3 similarly observed no beneficial effect in one patient with hemophilia who was given injections of large amounts of estrogenic substance over a period of three days. More recently, Brem and Leopold4 have reported negative observations on the coagulation time and clinical state of a patient
CHEW WB, STETSON RP, SMITH GVS, SMITH OW. ESTROGENIC, LUTEAL AND GONADOTROPIC HORMONES IN HEMOPHILIA. Arch Intern Med (Chic). 1935;55(3):431–444. doi:10.1001/archinte.1935.00160210084008
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