The importance of a determination of blood volume in clinical medicine has long passed the experimental stage. Sufficient work has been done to prove that an abnormal blood volume will sometimes throw light on the underlying cause of a disease, and that it is helpful in the differential diagnosis of such diseases as hyperthyroidism, polycythaemia vera and cardiovascular disease, constituting a valuable aid in prognosis and treatment.
Some clinicians, however, still deny the importance of studies of blood volume on the ground that there is no accurate method of determining the circulating blood volume. It is admitted that from the exact physiologic standpoint, the methods utilized are not absolute; but, on the basis of an immense amount of work by others and our own observations in a large series of cases, we are firmly convinced that the results obtained justify the application of studies of blood volume to clinical medicine.
GOLDBLOOM AA, LIBIN I. CLINICAL STUDIES IN CIRCULATORY ADJUSTMENTSI. CLINICAL EVALUATION OF STUDIES OF CIRCULATING BLOOD VOLUME. Arch Intern Med (Chic). 1935;55(3):484–511. doi:10.1001/archinte.1935.00160210137011
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