Since the introduction of parathyroidectomy as a cure for osteitis fibrosa cystica by Mandl,1 in 1926, interest in generalized bone diseases has increased greatly. The numerous chemical and clinical observations on Recklinghausen's disease since 1926 have established certain criteria for arriving at the diagnosis of hyperparathyroidism and for use as a basis for exploring and possibly removing one or more hyperfunctioning parathyroids. The disease is usually first recognized clinically either through the history of a fracture or pain in an extremity or by the presence of calcic deposits in unusual sites, such as the skin or pelvis of the kidney; and the diagnosis is further corroborated by the discovery of cysts or areas of degeneration as shown in roentgenograms of the bones. The final diagnosis, however, depends on the results of the determination of the calcium and phosphorus concentrations in the blood and excreta. The typical chemical findings in
SHELLING DH, VOSHELL AF. XANTHOMATOSIS GENERALISATA OSSIUMREPORT OF A CASE SIMULATING OSTEITIS FIBROSA CYSTICA. Arch Intern Med (Chic). 1935;55(4):592–608. doi:10.1001/archinte.1935.00160220062005
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