This report, the second of a series of studies of juvenile dementia paralytica, is confined to an analysis of the family history, particularly the incidence of syphilis, neurosyphilis and mental disease. A previous report1 covered the incidence, sex and age at onset. This study is based on 43 cases personally observed and 610 cases recorded in the literature.
INCIDENCE OF SYPHILIS IN FAMILY
Of the entire series of 653 cases the family history is detailed in 399 and is not given in 254. Syphilis in some form was demonstrated in one or more members of the family in 369 cases. Syphilis was demonstrated clinically or serologically (or both) in the mother in 223 cases, in the father in 226 cases and in one or more of the siblings in 114 cases.
Syphilis in the Mother.
—It is a recognized, established fact that the mother of a syphilitic child is
MENNINGER WC. JUVENILE DEMENTIA PARALYTICAII. FAMILY HISTORY, WITH SPECIAL CONSIDERATION OF FAMILIAL NEUROSYPHILIS. Arch Intern Med (Chic). 1935;55(4):626–642. doi:10.1001/archinte.1935.00160220096007
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