A number of investigators have reported studies of the concentration of plasma proteins at various periods of time following the administration of mercurial diuretics. The purpose of these studies was to establish evidence pointing to a renal or an extrarenal action of the drugs. Saxl and Heilig,1 Crawford and McIntosh,2 Bohn,3 Claussen4 and Meyer5 found a drop in plasma protein concentration during the first two hours after the injection of merbaphen or of salyrgan. In some instances this was followed later by a rise in the protein value. Others, notably Nonnenbruch,6 reported an increase in the protein concentration of the plasma following the administration of mercurial diuretics, whereas Bleyer7 found no constant changes. Meyer5 and Kylin8 observed a fall in the colloid osmotic pressure during the first hour after the administration of salyrgan, which they interpreted as evidence of an extrarenal action of the drug. Oelkers,9 on the other hand,
BRYAN AH, EVANS WA, FULTON MN, STEAD EA. DIURESIS FOLLOWING THE ADMINISTRATION OF SALYRGAN: ITS EFFECT ON THE SPECIFIC GRAVITY, THE TOTAL NITROGEN AND THE COLLOID OSMOTIC PRESSURE OF THE PLASMA OF NORMAL AND OF EDEMATOUS DOGS. Arch Intern Med (Chic). 1935;55(5):735–744. doi:10.1001/archinte.1935.00160230028002
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