In the hope of adding to the current knowledge of some of the little understood phases of cardiovascular syphilis, a study was begun in 1927 in the clinics for adults with cardiac disease and syphilis of the Brooklyn Hospital. The plan of the study was as follows: Every patient in the clinic for syphilis who would consent was referred to the clinic for cardiac disease for complete cardiovascular examination. This included taking a history and making a physical examination.1 Electrocardiograms and teleroentgenograms were taken, and Wassermann tests of the blood were made for nearly every patient. Of more importance, however, is the fact that these patients have been and, it is hoped, will be examined regularly in the clinic for cardiac disease at least every six months. The present paper is a preliminary report, giving an analysis of the facts observed in the first five years of the study.