The present studies have their genesis in an effort to open a new avenue of approach to the problem of thrombo-angiitis obliterans. Perusal of the literature adequately demonstrates the confusion surrounding the clinical and experimental aspects of this disturbance. What knowledge one has concerning the malady has been gleaned from purely clinical and statistical research. Experimental investigation,1 directed almost exclusively toward establishing a specific bacterial etiologic agent for the disease, has thus far either failed completely or the results have been so meager as to be altogether inconclusive. It would appear rather facetious to state that in an endeavor to reproduce experimentally a pathologic entity one must first know the pathology. Nevertheless it is here that the first difficulty is encountered. There is no unanimity of opinion among students of the disease regarding the pathology of thrombo-angiitis obliterans. Buerger,2 in his descriptions of the pathogenicity and chronologic pathology,
McGRATH EJG. EXPERIMENTAL PERIPHERAL GANGRENE: EFFECT OF ESTROGENIC SUBSTANCE AND ITS RELATION TO THROMBO-ANGIITIS OBLITERANS. Arch Intern Med (Chic). 1935;55(6):942–957. doi:10.1001/archinte.1935.00160240071004
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