It is well known that a disturbance in carbohydrate metabolism occurs in conditions in which there is an increase in heat production.
In reference to this subject Wilder1 made the following statements:
The exophthalmic goiter syndrome reduces the ability of the diabetic patient to utilize carbohydrate; decreases the efficiency of the unit of insulin; increases the danger of sudden onset of diabetic coma, and the control of this syndrome by the administration of iodine markedly improves the carbohydrate tolerance.... A mild and possibly inconspicuous or latent spark of diabetes may be fanned into flame by hyperthyroidism.... When thyroid is given to patients with diabetes, a marked intensification of glycosuria occurs and persists some time after the drug is discontinued.... An improvement in tolerance [in diabetes mellitus] has occurred within a week or ten days after thyroidectomy in almost every case.... Boothby and I have pointed out that the influence
WISHNOFSKY M, KANE AP, SHLEVIN EL, BYRON CS. INFLUENCE OF DI-NITROPHENOL ON CARBOHYDRATE METABOLISM. Arch Intern Med (Chic). 1935;56(2):374–381. doi:https://doi.org/10.1001/archinte.1935.03920020166011
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