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Article
August 1935

INFLUENCE OF DI-NITROPHENOL ON CARBOHYDRATE METABOLISM

Author Affiliations

BROOKLYN

From the Medical Service of Dr. S. R. Blatteis, Divisions of Diabetes and Metabolism, and the Department of Pathology of the Jewish Hospital, Brooklyn.

Arch Intern Med (Chic). 1935;56(2):374-381. doi:10.1001/archinte.1935.03920020166011
Abstract

It is well known that a disturbance in carbohydrate metabolism occurs in conditions in which there is an increase in heat production.

In reference to this subject Wilder1 made the following statements:

The exophthalmic goiter syndrome reduces the ability of the diabetic patient to utilize carbohydrate; decreases the efficiency of the unit of insulin; increases the danger of sudden onset of diabetic coma, and the control of this syndrome by the administration of iodine markedly improves the carbohydrate tolerance.... A mild and possibly inconspicuous or latent spark of diabetes may be fanned into flame by hyperthyroidism.... When thyroid is given to patients with diabetes, a marked intensification of glycosuria occurs and persists some time after the drug is discontinued.... An improvement in tolerance [in diabetes mellitus] has occurred within a week or ten days after thyroidectomy in almost every case.... Boothby and I have pointed out that the influence

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