From the many aspects that present themselves we have chosen to discuss in this paper the importance of disease of the sinuses in asthma and the evidence that infective asthma is an allergic reaction to bacteria or their products and that disease of the sinuses is usually the primary focus of infection; further, we present our data showing the effect of surgical intervention on the sinuses in asthma.
Wherever pathologic condition of the nasal passages is mentioned in connection with our cases of asthma, we refer to disease of the sinuses; as far as the literature is concerned, however, vasomotor changes, septal deviations and simple turbinal hypertrophies are included, and there is little or no attempt to differentiate the histologic type of disease of the sinuses, that is, the suppurative or the hyperplastic. In all our cases of asthma the membrane of the sinuses has been of the true hyperplastic
COOKE RA, GROVE RC. RELATION OF ASTHMA TO SINUSITIS: WITH SPECIAL REFERENCE TO THE RESULTS FROM SURGICAL TREATMENT. Arch Intern Med (Chic). 1935;56(4):779–789. doi:https://doi.org/10.1001/archinte.1935.00170020174007
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