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November 1935


Author Affiliations


From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School.

Arch Intern Med (Chic). 1935;56(5):864-876. doi:10.1001/archinte.1935.00170030032003

In the past, several investigators have postulated increased amounts of hormones of a pressor nature in the blood of patients with arterial hypertension. Others have suggested as a cause of hypertension the retention in the blood and tissues of metabolic products having a pressor action. One of us (Dr. Weiss1) has recently discussed these various theories, and a critical analysis with references can be found in that paper. In recent years, interest in the relation of such substances to hypertension has been stimulated again, largely through the work of two groups of investigators in Germany. Lange and Felix,2 in 1933, claimed to have found diminished amounts of a specific depressor substance in the blood and increased amounts in the urine of patients suffering from essential hypertension, and increased amounts in the blood and decreased amounts in the urine of patients with nephritic hypertension. They advanced the theory that