The intimate relationship of disease of the biliary tract to pancreatitis and its significance as an etiologic factor in the production of glycosuria and diabetes mellitus are generally recognized. Joslin1 stated that cholelithiasis is one of the important etiologic factors in cases of diabetes of adults. He emphasized the importance of eradicating disease of the gallbladder in this type of diabetes and cited several cases that demonstrated the favorable influence of this procedure on sugar tolerance.
Cammidge2 in a letter to the editor of the Lancet commented:
It has long been recognized that glycosuria is a relatively uncommon result of the chronic interstitial pancreatitis associated with gall-stones, and that when it does occur it is of a mild type. But the disease is usually progressive and, although operative interference may bring about an improvement in the patient's carbohydrate tolerance, it is only temporary and frank diabetes ultimately results.
LANDE H, POLLACK H. HYPERGLYCEMIA AND GLYCOSURIA ASSOCIATED WITH DISEASE OF THE BILIARY TRACT. Arch Intern Med (Chic). 1935;56(6):1097–1108. doi:10.1001/archinte.1935.00170040031002
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