A man (case 9,009) of quiet and controlled temperament was brought in an ambulance to the hospital. He was moaning and writhing in pain, although his pupils were already contracted by morphine administered for an attack of suspected ureteral colic. A second patient (case 10,349), a former football player and coach, was admitted to the hospital because of such unaccountable depression, restlessness and severe burning sensations in his feet that he could not sleep. A third patient (case 10,405) was admitted because paralysis of the muscles of the foot had prevented his working for the preceding two months. A fourth patient (case 8,428), a man 30 years of age, was admitted to the hospital because of gangrene following a burn from an electric pad applied to a painful foot and lower part of the leg. All four suffered from diabetic neuritis. In 1864 Marchal de Calvi drew attention to the