A group of young patients with the manifestations of diabetes mellitus, sexual infantilism and varying degrees of dwarfism has been observed. These patients not only present a definite syndrome but are of interest in view of the recent advances which have been made in the knowledge of the anterior lobe of the pituitary gland. They demonstrate the occurrence of diabetes mellitus in association with hypofunction of the anterior lobe of the hypophysis in spite of the improbability of such a combination as indicated by experimentation with animals. As the result of pituitary dysfunction, as evidenced by dwarfism or at least by delayed adolescence, diabetic symptoms if present should be mild. In all eight cases the condition has been severe.
The functions of the anterior lobe of the pituitary gland have been summarized by Evans,1 who ascribed to it growth, gonadotropic, lactogenic, thyrotropic and adrenotropic hormones; in addition to a
R. B. GIBSON, W. M. FOWLER. INFANTILISM AND DIABETES MELLITUSA REPORT OF EIGHT CASES. Arch Intern Med (Chic). 1936;57(4):695–707. doi:10.1001/archinte.1936.00170080049003