In a study of the nitrogenous exchange of patients with Bright's disease, it was suggested by Peters that the nonprotein nitrogen content of the urine provides more significant data than the total nitrogen content of the urine. In the course of experiments designed to test the validity of this suggestion and others, we studied the total amounts of nitrogen and sulfur and compared these figures with the values for the total nonprotein nitrogen and nonprotein sulfur in the urine of patients with albuminuria.
The difference between the total nitrogen and sulfur content of the urine as voided and that of the protein-free filtrate of the same specimen of urine gives the nitrogen and sulfur content of the protein excreted. We were struck with the low sulfur content of the protein excreted by patients with "nephrosis" and extended the investigation to include the study of other types of proteinuria.
GRABFIELD G, PRESCOTT B. STUDIES ON NITROGEN AND SULFUR METABOLISM IN BRIGHT'S DISEASE: VII. SULFUR CONTENT OF URINARY PROTEIN. Arch Intern Med (Chic). 1936;57(6):1081–1084. doi:10.1001/archinte.1936.00170100022003
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: