Although disease of the renal arterioles is the most constant morphologic expression of essential hypertension, derangement of renal function leading to death from uremia occurs in only a small number of patients with this disease. However, the attention of physicians has been so focused on the possibility of this dread outcome for persons with hypertension that they are accustomed to undertake a careful study of the renal function of their patients in the hope of assuring them that uremia is remote. It becomes pertinent to inquire into the merits of the various tests proposed for measuring renal function in the hope of selecting those which are simple and inexpensive in execution and delicate in response. The latter, more important, requirement is in part a matter of interpretation. It will depend on a strict definition of the degree of variation in result when the test is performed on normal persons. When
ELLIOT AH, NUZUM FR. EVALUATION OF MEASURES OF RENAL FUNCTION IN PERSONS WITH ARTERIOSCLEROTIC BRIGHT'S DISEASE. Arch Intern Med (Chic). 1936;57(6):1151–1162. doi:10.1001/archinte.1936.00170100096009
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