Loss of blood over a long period leads to hypochromic anemia, which may properly be attributed to depletion of the iron stored in the body. Regeneration of hemoglobin in patients with uncomplicated anemia of this type occurs after cessation of the hemorrhage with the aid of appropriate iron therapy. One of the frequent causes of this type of anemia is prolonged or recurrent loss of blood from a peptic ulcer. In patients with depletion of stored iron due to a bleeding ulcer, dietary iron alone is insufficient to stimulate rapid formation of hemoglobin, and chronic anemia often persists after the bleeding is stopped.
A common method of treating peptic ulcer is the modified Sippy regimen. This requires the use of large amounts of alkaline powders daily over a long period. Such treatment obviously renders alkaline the contents of the upper part of the gastro-intestinal tract. In recent years it has
KELLOGG F, METTIER SR. EFFECT OF ALKALINE THERAPY FOR PEPTIC ULCER ON UTILIZATION OF DIETARY IRON IN THE REGENERATION OF HEMOGLOBIN. Arch Intern Med (Chic). 1936;58(2):278–284. doi:10.1001/archinte.1936.00170120094007
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