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Article
September 1936

THE ETIOLOGIC SIGNIFICANCE OF STREPTOCOCCI IN EPIDEMIC ENCEPHALITIS: II. EXPERIMENTS WITH ANIMALS AND CONCLUSIONS

Author Affiliations

ST. LOUIS

From the Department of Bacteriology, Immunology, and Public Health, Washington University Medical School.

Arch Intern Med (Chic). 1936;58(3):469-494. doi:10.1001/archinte.1936.00170130098006
Abstract

In a previous paper1 we described the biologic properties of the streptococci obtained from patients with encephalitis, their agglutination reactions with Rosenow's encephalitis antistreptococcus serum and their cataphoretic velocity and compared these data with those obtained by a parallel study of similar cultures from normal persons residing in St. Louis, as well as in a locality far removed from the area of the epidemic. It is the purpose of this communication to describe the results which followed intracerebral inoculation of the cultures obtained from patients and from normal persons into animals and our experiments bearing on the immunologic relationship of the streptococci isolated to clinical encephalitis.

TECHNIC  As in the previously reported work we were at particular pains in the experiments with animals to follow in all essential details the procedures used by Dr. Rosenow, who was kind enough to give us a full personal demonstration. Dr. Rosenow in

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