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February 1937


Arch Intern Med (Chic). 1937;59(2):299-328. doi:10.1001/archinte.1937.00170180126006

In a study of Recklinghausen's neurofibromatosis, a system disease, one is immediately impressed with (1) the lack of a known etiologic factor, (2) the apparent widespread differences of the various clinical types and (3) the lack of any known beneficial treatment. Though a great number of isolated cases have been reported,1 there has been comparatively little attempt to weave together the many loose threads of this clinicopathologic syndrome. During the past three years thirty-one patients with Recklinghausen's neurofibromatosis have been observed. In this report it is proposed to demonstrate examples of the multiple manifestations of the condition and to emphasize the influence of various physiologic factors and life experiences on the disease.

ETIOLOGY  Though many theories have been advanced, the cause of Recklinghausen's neurofibromatosis is unknown. The disease is not limited to the white population but has been reported in the black, red and yellow races also.