From 1667, when the first blood transfusion was given to man by Jean Baptiste Denys,1 until the discovery of hemagglutination by Landsteiner2 in 1901 and the classification of blood groups by Janský3 (1907) and Moss4 (1910), hemoglobinuria was accepted as a common accompaniment of the injection of blood intravenously. In many of the patients who showed hemoglobin in the urine renal insufficiency developed, and death followed. Since testing the donor's and the recipient's blood for agglutination has become common, the incidence of severe complications from blood transfusions has, fortunately, greatly diminished. Hesse and Filatov18a reported a mortality of 1.3 per cent from 750 transfusions in Leningrad. They estimated that in general the mortality in various clinics was between 0.5 and 1.5 per cent. Tiber5 (1930) reported 2 deaths from 1,467 transfusions (0.013 per cent) at Bellevue Hospital. Witts6 described 3 deaths in 3,430 transfusions in Great
DeGOWIN EL, OSTERHAGEN HF, ANDERSCH M. RENAL INSUFFICIENCY FROM BLOOD TRANSFUSION: I. RELATION TO URINARY ACIDITY. Arch Intern Med (Chic). 1937;59(3):432–444. doi:10.1001/archinte.1937.00170190067004
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