Although the symptomatic and, to some extent, the pathologic results which accompany states of marked deprivation of vitamins have been largely described, great interest has been shown in the past year in the early alterations in normal physiologic processes which occur before these gross pathologic changes have become manifest. In fact, chief interest in the field of nutrition is at present directed toward studies of the metabolic influences of the various vitamins. Of particular interest to clinicians have been methods of recognition and treatment of states of moderate and mild vitamin deficiency, the effect of abnormalities in gastro-intestinal function in the production or conditioning of disease due to vitamin deficiency, studies of the metabolism of vitamin C and, lastly, studies of the physiologic properties of the vitamin B complex, elucidation of the components of which has advanced steadily.
The daily requirement of vitamin A is still unknown. Indeed,
WILDER RM, WILBUR DL. DISEASES OF METABOLISM AND NUTRITION: REVIEW OF CERTAIN RECENT CONTRIBUTIONS. Arch Intern Med (Chic). 1937;59(3):512–555. doi:10.1001/archinte.1937.00170190147008
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