The metabolism of carbohydrate and fat results in almost complete oxidation or storage of these substances in the body. In contrast, the metabolism of protein leads to the formation of several end-products that are eliminated by the kidney, and the excretion of these products entails work by the kidney. The possibility that this work or some specific product or products may eventually lead to pathologic changes in this organ has been the incentive for much study. The results obtained by feeding animals, chiefly rabbits and rats, diets high in protein have been conflicting. Many of the early investigations are open to the criticism that the necessary food accessories were missing from the diet. The use of rabbits for this type of study is questionable, unless the effects of vegetable proteins are being determined. That in these animals spontaneous nephritis is prone to develop is, in any case, disturbing. The nutritive
BLATHERWICK NR, MEDLAR EM. CHRONIC NEPHRITIS IN RATS FED HIGH PROTEIN DIETS. Arch Intern Med (Chic). 1937;59(4):572–596. doi:10.1001/archinte.1937.00170200014002
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