The recognition of the functions of the various endocrine glands and of the importance of the hormones which they produce is one of the recent developments in medicine. The adrenal glands, for example, were described by Eustachius in 1563, but nearly three hundred years elapsed before there was any real insight into their physiologic activity. In 1855 Addison pointed out the constitutional effects of disease of these glands and established the clinical syndrome which bears his name. The experiments of Oliver and Schäfer in 1895 paved the way for the isolation and chemical identification of epinephrine by Abel and Takamine a few years later.
The last-mentioned discovery focused attention on the medullary portion of the adrenal gland, and the majority of subsequent investigations have dealt with the functional activity of the medulla. Other experiments, however, have been concerned with the effects of partial or complete extirpation of these glands. These
GREENE CH. CLINICAL USE OF EXTRACT OF THE ADRENAL CORTEX: REPORT ON THIRTY-FOUR CASES OF ADDISON'S DISEASE STUDIED BETWEEN 1930 AND 1937, WITH A REVIEW OF THE LITERATURE. Arch Intern Med (Chic). 1937;59(5):759–784. doi:10.1001/archinte.1937.00170210002001
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.