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Article
May 1937

NITROGEN AND SULFUR METABOLISM IN BRIGHT'S DISEASEVIII. EFFECT OF INGESTION OF UREA ON NITROGEN EXCRETION AND SULFUR PARTITION IN NEPHROSIS, GLOMERULONEPHRITIS AND CIRRHOSIS OF LIVER

Arch Intern Med (Chic). 1937;59(5):823-836. doi:10.1001/archinte.1937.00170210066004
Abstract

Previous studies have called attention to the strongly positive nitrogen and sulfur balances in patients with the nephrosis syndrome1 and to the tendency to negative balances in patients with chronic glomerulonephritis.2 More recently retention of urea was noted in a patient with nephrosis,3 confirming the earlier observations of Peters.4 Later observations by Peters5 were interpreted by him as indicating a similar retention of urea fed to normal subjects, though of lesser degree than was the case in patients with nephrosis. These conclusions were contested by Kocher and Torbert,6 who, however, failed to repeat Peters' experimental conditions, as they studied subjects on protein-free diets whereas all the other experiments were done by feeding urea to subjects on an adequate mixed diet. It seemed desirable to see if further experiments could be devised to reconcile the contradictory findings, which may be summarized as follows: Peters reported the retention of huge amounts of

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